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KMID : 0043320060290090728
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Archives of Pharmacal Research
2006 Volume.29 No. 9 p.728 ~ p.734
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Synthesis of 7-Hydroxy-4-Oxo-4H-Chromene- and 7-Hydroxychroman-2-Carboxylic Acid N-Alkyl Amides and Their Antioxidant Activities
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Kwak Jae-Hwan
Kang Hae-Eun
Jung Jae-Kyeong
Kim Hwa-Jung
Cho Jung-Sook
Lee Hee-Soon
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Abstract
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A series of 7-hydroxy-4-oxo-4H-chromene- (3a - h) and 7-hydroxychroman-2-carboxylic acid N-alkyl amides (4a - g) were synthesized and their antioxidant activities were evaluated. While compounds 3a - h were less active, compounds 4a - g exhibited more potent inhibition of lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Among them, 7- hydroxychroman-2-carboxylic acid N-alkylamides (4e - g) bearing nonyl, decyl, and undecyl side chain exhibited 3 times more potent inhibition than trolox (1).
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KEYWORD
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Antioxidant activity, 7-Hydroxychroman-2-carboxylic acid N-alkyl amides
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